Advancements in healthcare technology and science are disrupting the paradigm for the most expensive hotel in town--the hospital, especially since the COVID-19 pandemic. Clinicians, entrepreneurs, and policymakers are re-thinking how to enable the home as the center for healthcare delivery. Navigating the digital divide while catalyzing on innovation in telemedicine, diagnostics, and remote patient monitoring technologies will be crucial. New business models are being generated, in part due to policy and regulation changes.  Competition amongst stakeholders is heightening as the U.S. further explores how to satisfy  patients' desire to get better at home.